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CSA 311 CLINICAL PHARMACOKINETICS LECTURE NOTES ONLINE

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Introduction

1. Course objective and assessments
2. Course outline
3. Do you need to be here?

Biopharmaceutics Lecture notes:

0. Preface and contents
1. Introduction
2. Bioavailability - concepts and factors influencing oral bioavailability of drugs (4 lectures)
3. Bioavailability testing
4. Bioavailability from other routes of administrations (2 lectures)
5. Drug delivery systems (6 lectures)

Pharmacokinetics Lecture Notes:

0. Preface and contents
1. Introduction
2. Pharmacokinetic models and ADME processes (5 lectures)
3. Pharmacokinetics of IV bolus injections
4. Pharmacokinetics of IV infusion
5. Pharmacokinetics of extravascular administration - single doses and multiple doses (3 lectures)
6. Metabolite kinetics
7. Non-linear kinetics (2 lectures)
8. Other routes of drug elimination - bile, breast milk, etc
9. Kinetics of pharmacological responses
10. Plasma protein binding of drugs (2 lectures)
11. Hepatic Extraction Ratio
12. Therapeutic drug monitoring
13. Effects of age, gender, posture and altered physiological states on pharmacokinetics (5 lectures)
14. Pharmacokinetics and cardiovascular disease
15. Pharmacokinetics and hepatic disease
16. Pharmacokinetics and renal disease (2 lectures)
17. Clinical pharmacokinetics of Theophylline (2 lectures)
18. Clinical pharmacokinetics of Digoxin
19. Clinical pharmacokinetics of Lignocaine
20. Clinical pharmacokinetics of the Aminoglycosides (2 lectures)
21. Clinical pharmacokinetics of Warfarin
22. Clinical pharmacokinetics of NSAID’s
23. Clinical pharmacokinetics of Anticonvulsants
24. Clinical pharmacokinetics of Lithium
25. Clinical pharmacokinetics of the Tricyclic Antidepressants
26. Clinical pharmacokinetics of the Antipsychotic drugs
27. Clinical pharmacokinetics of the Opioids (2 lectures)

Case study Book

PDF Format (requires Adobe Acrobat - Mac or PC) - 177kb
Microsoft Word format (requires Microsoft Word viewer - PC only) - 160kb

Links to other sites:

Pharmacokinetic and pharmacodynamic resources
Basic pharmackinetics course notes
Clinical Pharmacology online
Pharmacist relevant sites
Tasmanian School of Pharmacy