 |
Web Hosting by Netfirms | Free Domain Names by Netfirms |
|
|
|
|
BIOPHARMACEUTICS |
 |
Biopharmaceutics:
Study of the relationship between physiochemical and formulation properties of a drug in a dosage form and the therapeutic response observed after its administration.
OR
The study of factors that influence the rate and extent of absorption of a drug from a dosage form into the systemic circulation (ie. “bioavailability” of the drug from the dosage form).
Importance of Biopharmaceutics:
- Bioequivalence:
Different formulations with comparable bioavailabilities.
- Comparing bioavailability:
(i) Extent of absorption:
- AUC.
- Urinary excretion.
(ii) Rate of absorption:
- Time to peak level (tp).
- Absorption rate constant (ka).
- Practical problems in relation to bioequivalence.
- Reasons to aim for maximum bioavailability.
TABLE: Drugs With Potential Bioequivalency Problems
Acetazolamide
Hydrochlorothiazide
Promethazine
Acetyldigitoxin
Hydroflumethiazide
Propylthiouracil
Alseroxylon
Imipramine
Pyrimethamine
Aminophyllin
Isoproterenol
Quinethiazide
Aminosalicylic acid
Liothyronine
Quinidine
Bendroflumethiazide
Menadione
Rauwolfia serpentina
Benzthiazide
Mephenytoin
Rescinnamine
Betamethasone
Methazolamide
Reserpine
Bishydroxycoumarin
Methyclothiazide
Salicylazosulfapyridine
Chlorambucil
Methylprednisolone
Sodium sulfoxone
Chlorodiazepoxide
Methyltestosterone
Spironolactone
Chlorothiazide
Nitrofurantoin
Sulfadiazine
Chloropromazine
Oxtriphylline
Sulfadimethoxine
Cortisone-acetate
Para-aminosalicylic acid
Sulfamerazine
Deserpidine
para-methadione
Sulfaphenazole
Dexamethasone
Perphenazine
Sulfasomidine
Dichlorphenamide
Phenacemide
Sulfasoxazole
Dienestrol
Phensuximide
Theophylline
Diethylstilbestrol
Phenylaminosalicylate
Thioridazine
Dyphylline
Phenytoin
Tolbutamide
Ethinyl estradiol
Phytonadione
Triamcinolone
Ethosuxmide
Polythiazide
Trichlormethiazide
Ethotoin
Prednisolone
Triethyl melamine
Ethoxzolamide
Primidone
Trifluoperazine
Fludrocortisone
Probenecid
Triflupromazine
Fluphenazine
Procainamide
Trimeprazine
Fluprednisolone
Prochlorperazine
Trimethadione
Hydralazine
Promazine
Uracil mustand
Warfarin
   |
